Introducing Polar+

Fast, precise protein analysis, bundled in a strong drug discovery platform. Launching soon.


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At the atomic level

Polar+ protein pruning technology finds the best binding sites on a protein by comparing binding energies at every atom. Not only does this provide strong information for further kinetics modeling, but it also helps in the incorporation of subtler, electromagnetic effects between atoms. This also means that our tool can help complete protein-ligand and large protein-protein models with little setup time. Read more about our methodology here

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Quantum Algorithms and Quantum Devices, Today

We model atoms on both real quantum devices and large scale cloud infrastructures utilizing CPUs and GPUs. We have written algorithms and workflows around IBM's, Rigetti's, and DWave's quantum computers, and are currently finishing up work within Xanadu and CMC's Quantum Sandbox program. .



Publications and Completed Projects

As we prepare to publically launch Polar+, we have been working on sets of software tools and research papers to determine our technologies' strengths and weaknesses.

G/SG Morph

The Graph/Subgraph Isomorphism Library for Quantum Annealers, based off of Calude, Dinneen, and Hua’s paper “QUBO formulations for the graph isomorphism problem and related problems” . This library was recently cited (entry 499, update.pdf) in an update to the University of Auckland CDMTCS (Centre for Discrete Mathematics and Theoretical Computer Science) report of the same title and authorship as the previously mentioned paper.

Boson Sampling Library

A library to better understand Aaronson-Arkhipov Boson Sampling. The Boson Sampling Library contains dedicated functions for calculating the submatrix of Interferometer matrices as well as the photon detection probabilities with the help of Xanadu's The Walrus library.

American Thoracic Society Presentation: In Silico Comparison of SP-A and ACE2 Binding to the SARS-CoV-2 Spike Protein Using Quantum Computing

An investigation into the potential binding of Surfactant Protein-A (SP-A) and the SARS CoV-2 spike protein that utilized Polar+'s protein pruning technology to find top binding spots on both proteins before binding analysis with ZDOCK, completed in collaboration with UC Davis Medical Center's Lung Biology Center .

American Thoracic Society Presentation: Role of Surfactant Protein D (SP-D) in COVID-19

An investigation into the potential binding of Surfactant Protein-D (SP-D) and the SARS CoV-2 spike protein that utilized Polar+'s protein pruning technology to find top binding spots on both proteins before binding analysis with ZDOCK, completed in collaboration with UC Davis Medical Center's Lung Biology Center . This work also featured analysis into the RNA prevalence of SARS CoV-2 in mice after SP-D was removed, as well as SP-D prevalence in COVID patients at the UC Davis Medical Center in order to further verify or refute computational binding results.

Quantum Approximated Graph Cutting: A Rapid Replacement for T-REMD?

An investigation into the potential binding of Surfactant Protein-A (SP-D) and the SARS CoV-2 spike that utilized Polar+'s protein pruning technology on the Rigetti Aspen to find top binding spots on both proteins before binding analysis with ZDOCK, completed in collaboration with the Bioinformatics Group of the International Scientific-Education Center at the National Academy of Science, Republic of Armenia. This work also featured Temperature Replica Exchange Molecular Dymanics (T-REMD) from GROMACS running on the BRIDGES and JUEWELS supercomputing clusters, and a completely classical version of the Polar+ protein pruning software that utilized Goemans-Williamson's MaxCut algorithm to serve as points of comparison against results from the quantum algorithm running classically and running on the Aspen device.

Energetics Based Modeling of Hydroxychloroquine and Azithromycin Binding to the SARS-CoV-2 Spike (S)Protein - ACE2 Complex

An investigation looking to determine if there was a potential binding interaction between the hydroxychloroquine and azithromycin drug combo and the SARS CoV-2 spike - ACE2 complex that utilized Polar+'s protein pruning technology to find top binding spots on both proteins before binding analysis with Autodock Vina. This work has been cited by Pfizer , the Italian National Research Council , and at least 24 other researchers.



About us

If and Only If (Iff) Technologies is a small company from Davis, CA focused on the development of new software that can help to improve the development of biomaterials. Follow us on Linkedin and Github to stay up to date on our progress!